The BIRC6 Polyclonal Antibody (PAC017595) is a valuable tool for researchers studying the role of BIRC6 in cancer biology. BIRC6, also known as Bruce, is a member of the inhibitor of apoptosis (IAP) family of proteins, which play a crucial role in regulating cell survival and apoptosis. This antibody, raised in rabbits, is highly specific to human BIRC6 and has been validated for use in Western blot applications.BIRC6 is known to be overexpressed in various cancer types, where it promotes tumor cell survival and resistance to chemotherapy.
By targeting BIRC6 with this antibody, researchers can gain insights into the molecular mechanisms underlying cancer progression and potentially identify new therapeutic targets for cancer treatment.This antibody is an essential tool for scientists working in the fields of oncology, cell biology, and drug discovery. Its high specificity and sensitivity make it ideal for detecting BIRC6 expression in cancer cells and tissues, providing valuable information for understanding the role of this protein in cancer development and progression.
Antibody Name:
BIRC6 Antibody (PACO17595)
Antibody SKU:
PACO17595
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human BIRC6
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17595(BIRC6 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO17595(BIRC6 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.
Synonyms:
Baculoviral IAP repeat-containing protein 6
UniProt Protein Function:
BIRC6: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8. Expressed in brain cancer cells. Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.
UniProt Protein Details:
Protein type:Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19; EC 6.3.2.-
Biological Process: mitosis; apoptosis; cell division; positive regulation of cell proliferation; protein ubiquitination; regulation of cytokinesis; protein amino acid phosphorylation; negative regulation of apoptosis; regulation of cell proliferation
NCBI Summary:
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
