The BIRC5 Polyclonal Antibody (CAB1551) is a valuable tool for researchers investigating BIRC5, a protein also known as survivin that plays a crucial role in regulating cell division and inhibiting apoptosis. This antibody, produced in rabbits, is highly specific for human BIRC5 samples and has been validated for use in Western blot applications. By binding to the BIRC5 protein, this antibody enables accurate detection and analysis in various cell types, making it an ideal choice for studies in cancer biology and cell cycle regulation.
BIRC5 is a key player in promoting cell survival and preventing programmed cell death, making it a potential target for therapeutic interventions in cancer treatment. Its overexpression has been implicated in various types of cancer, highlighting the importance of understanding its function and regulation in disease progression. By using the BIRC5 Polyclonal Antibody, researchers can delve deeper into the mechanisms underlying cancer development and explore novel strategies for targeted therapy.
Product Name:
Survivin Rabbit Polyclonal Antibody
SKU:
CAB1551
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human Survivin (NP_001159.2).
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
332
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Survivin Rabbit pAb (CAB1551) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
