The Biotinylated Anti-TIM3 Antibody (HDLA045) is a valuable tool for researchers studying T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a cell surface receptor involved in immune regulation and tolerance. This antibody, raised against TIM3 in rabbits, exhibits high specificity and sensitivity in detecting TIM3 protein in human samples. Validated for use in various applications such as immunohistochemistry and flow cytometry, it allows for precise identification and quantification of TIM3 expression in different cell types.TIM3 is known to play a crucial role in T cell exhaustion, a state of dysfunction that occurs in chronic infections and cancer. By binding to its ligands, TIM3 can regulate T cell responses and contribute to immune escape mechanisms employed by tumors.
Research on TIM3 has implications in understanding immune dysfunction in cancer, viral infections, and autoimmune diseases, paving the way for developing targeted therapies that restore T cell function and enhance anti-tumor immunity.The Biotinylated Anti-TIM3 Antibody (HDLA045) offers researchers a reliable tool to explore the role of TIM3 in immune modulation and its potential as a therapeutic target in various diseases. Its high specificity and versatility make it an essential component in studies focusing on immune checkpoints and T cell dysfunction in cancer and other immune-related disorders.
SKU:
HDLA045
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM83
Synonyms:
HAVCR2, TIM3, TIMD3, FLJ14428, KIM3
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
