The Biotinylated Anti-Mesothelin Antibody (HDLA034) is a highly specific and sensitive tool for research involving mesothelin, a cell surface protein with implications in cancer biology. The antibody, produced through biotinylation for enhanced detection, is validated for use in various applications such as immunohistochemistry, flow cytometry, and ELISA.Mesothelin, a glycosylphosphatidylinositol-anchored protein, is overexpressed in various types of cancer, including mesothelioma, ovarian, and pancreatic cancer. Its role in tumor progression and metastasis makes it a promising target for cancer diagnostics and therapy development.
The Biotinylated Anti-Mesothelin Antibody enables precise detection and quantification of mesothelin expression in tissue samples, facilitating further understanding of its involvement in cancer biology.Researchers in oncology, pathology, and molecular biology can benefit from the high specificity and sensitivity of the Biotinylated Anti-Mesothelin Antibody for their studies on cancer biomarkers and targeted therapies. By utilizing this antibody, scientists can advance their research in developing novel treatment strategies for mesothelin-expressing cancers.
SKU:
HDLA034
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM72
Synonyms:
MSLN, Mesothelin, MPF
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
