The Biotinylated Anti-GITR Antibody (HDLA041) is a valuable tool for researchers studying glucocorticoid-induced tumor necrosis factor receptor (GITR), a cell surface protein involved in immune regulation. This antibody, produced through biological processes, is highly specific for human samples and is optimized for use in various immunoassays, including Western blotting and immunohistochemistry.GITR, also known as TNFRSF18, plays a critical role in modulating immune responses by promoting T-cell activation and survival.
Its involvement in regulating immune function makes it a promising target for studying diseases like cancer, autoimmune disorders, and infectious diseases. By utilizing the Biotinylated Anti-GITR Antibody, researchers can effectively detect and analyze GITR expression in different cell types, aiding in the exploration of its role in immune response modulation and potential therapeutic interventions.
SKU:
HDLA041
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM79
Synonyms:
AITR, GITR, TNFRSF18, CD357
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25( )CD4( ) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
