The Biotinylated Anti-CD38 Antibody (HDla003) is a valuable tool for researchers studying CD38, a transmembrane glycoprotein involved in immune cell function and signaling. This antibody, produced in-house and conjugated with biotin for easy detection and analysis, is highly specific for human CD38 and is suitable for various applications, including flow cytometry and immunofluorescence.CD38 is known for its role in immune cell activation, proliferation, and differentiation, making it a key target in immunology and cancer research. By binding to CD38 and allowing for its visualization and quantification, this antibody enables researchers to study the expression and function of CD38 in different cell types and physiological conditions.
With its high specificity and sensitivity, the Biotinylated Anti-CD38 Antibody (HDla003) provides a reliable tool for investigating the potential therapeutic applications of targeting CD38 in diseases such as cancer, autoimmune disorders, and inflammatory conditions. Its versatility and ease of use make it an essential reagent for researchers exploring the role of CD38 in immune regulation and disease pathogenesis.
SKU:
HDLA003
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM29
Synonyms:
T10, cADPr hydrolase 1
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2 . The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
