The Biotinylated Anti-CD27 Antibody (HDLA021) offered by Assay Genie is a valuable tool for researchers studying CD27, a cell surface molecule that plays a key role in immune responses. This rabbit-derived antibody is highly specific to human samples and is validated for use in various applications, including Western blotting. By binding to the CD27 protein, this antibody allows for the detection and analysis of CD27 expression in different cell types, making it an ideal choice for studies in immunology and cancer research.CD27, also known as a co-stimulatory molecule, is essential for activating T cells and promoting immune responses.
Its involvement in regulating immune function makes it a promising target for investigating diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By understanding the role of CD27 in immune modulation, researchers can potentially develop targeted therapies that manipulate immune responses in these diseases.Overall, the Biotinylated Anti-CD27 Antibody (HDLA021) from Assay Genie provides a reliable tool for studying the function of CD27 and its impact on immune responses, offering valuable insights for researchers in the field of immunology and cancer research.
Product Code:
HDLA021
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM58
Synonyms:
CD27, TNFRSF7, S152, T14, Tp55
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
