The Biotinylated Anti-41BB Antibody (HDLA028) is a valuable tool for research involving the 41BB protein, a member of the tumor necrosis factor receptor superfamily that is known to play a key role in regulating immune responses. This antibody, produced using biotinylated technology, is highly specific and sensitive for detecting 41BB in various experimental settings.The 41BB protein, also referred to as CD137, is an important co-stimulatory molecule expressed on activated T cells, which enhances T cell proliferation, survival, and cytokine production. By targeting 41BB, researchers can gain insights into the mechanisms underlying immune activation and potentially develop new immunotherapy strategies for diseases like cancer and autoimmune disorders.
The Biotinylated Anti-41BB Antibody (HDLA028) is an essential tool for studying the function and expression of 41BB in immune cells, providing researchers with a valuable tool for investigating the role of this protein in immune regulation and disease pathogenesis. Its high specificity and sensitivity make it a reliable reagent for various immunology and oncology research applications.
SKU:
HDLA028
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM66
Synonyms:
TNFRSF9, 4-1BB, CD137, CDw137, ILA
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
