The Biotin Anti-Human CD3 Antibody (UCHT1) offered by AssayGenie is a valuable tool for researchers studying immune responses and T-cell biology. This antibody specifically targets the CD3 protein on human T cells, a crucial component of the T-cell receptor complex involved in immune activation and regulation.This biotinylated antibody is well-suited for various experimental applications, including immunohistochemistry, flow cytometry, and immunoprecipitation. Its high specificity and sensitivity ensure reliable detection and analysis of CD3 expression in different cell types and tissue samples.
By targeting the CD3 protein, researchers can gain insights into T-cell function, activation, and differentiation, providing valuable information for studies related to immunology, infectious diseases, autoimmune disorders, and cancer immunotherapy. The Biotin Anti-Human CD3 Antibody (UCHT1) is a versatile tool that supports a wide range of research endeavors focused on understanding and manipulating immune responses for therapeutic purposes.
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:
P07766
Gene ID:
915
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD3ε is a 20 kD chain of the CD3/T cell receptor (TCR) complex, which is composed of two CD3ε, one CD3γ, one CD3δ, one CD3ζ (CD247), and a T cell receptor (α/β or γ/δ) heterodimer. It is found on all mature T lymphocytes, NK T cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation.