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Biotin Anti-Human CD123 Antibody [6H6] (AGEL3259)

SKU:
AGEL3259
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG1, k
Clone:
6H6
Conjugation:
Biotin
$251 - $719
Frequently bought together:

Description

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Biotin Anti-Human CD123 Antibody [6H6]

The Biotin Anti-Human CD123 Antibody (6H6) offered by AssayGenie is a cutting-edge tool for researchers studying CD123, a cell surface marker primarily found on plasmacytoid dendritic cells and certain leukemic cells. This antibody, engineered for high specificity and sensitivity in human samples, is optimized for various applications including immunofluorescence, flow cytometry, and immunohistochemistry.CD123, also known as interleukin-3 receptor alpha chain, is a key molecule involved in the development and function of dendritic cells and plays a crucial role in the pathogenesis of certain hematopoietic malignancies. The Biotin Anti-Human CD123 Antibody (6H6) enables precise detection and analysis of CD123 expression in different cell types, making it an invaluable tool for research in immunology, hematology, and oncology.

Given the potential implications of CD123 in cancer progression and immune dysregulation, understanding its expression and function is essential for developing targeted therapies and diagnostic tools. The Biotin Anti-Human CD123 Antibody (6H6) from AssayGenie promises reliable and reproducible results, empowering researchers to delve deeper into the complexities of CD123 biology for innovative discoveries in disease management and treatment strategies.

Product Title:Biotin Anti-Human CD123 Antibody [6H6]
SKU:AGEL3259
Size:25µg, 100µg
Clone No:6H6
Synonyms:IL-3Rα; IL-3 Receptor alpha;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Biotin Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P26951
Gene ID:3563
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD123 is the 70 kD transmembrane α chain of the IL-3 receptor. Alone, CD123 binds IL-3 with low affinity; when CD123 associates with CDw131 (common β chain), it binds IL-3 with high affinity. CD123 does not transduce intracellular signals upon binding IL-3 and requires the β chain for this function. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and some B cells.

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