BIN1 Rabbit Polyclonal Antibody (CAB1792)
- SKU:
- CAB1792
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
Product Name: | BIN1 Rabbit Polyclonal Antibody |
SKU: | CAB1792 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-409 of human BIN1 (NP_647601.1). |
Sequence: | QNLN DVLV GLEK QHGS NTFT VKAQ PSDN APAK GNKS PSPP DGSP AATP EIRV NHEP EPAG GATP GATL PKSP SQSS LPAV VVET FPAT VNGT VEGG SGAG RLDL PPGF MFKV QAQH DYTA TDTD ELQL KAGD VVLV IPFQ NPEE QDEG WLMG VKES DWNQ HKEL EKCR GVFP ENFT ERVP |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:20 - 1:50 |
Synonyms: | CNM2; AMPH2; AMPHL; SH3P9; BIN1 |
Positive Sample: | Jurkat,HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 65kDa |
Observed MW: | 65kDa |
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Purification Method: | Affinity purification |
Gene ID: | 274 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |