The Bim Polyclonal Antibody (CAB12554) offered by AssayGenie is a valuable tool for researchers studying the Bim protein, a pro-apoptotic factor involved in regulating cell death. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it an excellent choice for Western blot applications.The Bim protein is a critical regulator of apoptosis, playing a key role in maintaining cellular homeostasis and eliminating damaged or unwanted cells. Dysregulation of Bim expression has been linked to various diseases, including cancer and neurodegenerative disorders, making it an intriguing target for therapeutic intervention.
By using the Bim Polyclonal Antibody, researchers can detect and analyze the expression of Bim in various cell types, aiding in the study of apoptosis pathways and potential therapeutic strategies. This antibody is a valuable tool for investigators in the fields of oncology, neuroscience, and cell biology, providing insights into the role of Bim in health and disease.
Product Name:
Bim Rabbit Polyclonal Antibody
SKU:
CAB12554
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-130 of human Bim (NP_619527.1).
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
Purification Method:
Affinity purification
Gene ID:
10018
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human tonsil using Bim Rabbit pAb (CAB12554) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
