The Biglycan Polyclonal Antibody (CAB5770) is a valuable tool for researchers studying biglycan, a small leucine-rich proteoglycan that plays a crucial role in extracellular matrix organization and cell signaling. This antibody, developed in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications, making it an ideal choice for investigations in the fields of biology and medicine.Biglycan is known to interact with various growth factors, cytokines, and receptors, influencing processes such as cell adhesion, migration, proliferation, and differentiation. Its dysregulation has been associated with various diseases, including cancer, cardiovascular disorders, and musculoskeletal conditions.
By targeting biglycan with this antibody, researchers can gain valuable insights into its function and potential therapeutic implications in these disease contexts.Furthermore, the Biglycan Polyclonal Antibody provides researchers with a powerful tool for detecting and quantifying biglycan levels in different cell types and tissues, facilitating the analysis of its biological roles and regulatory mechanisms. This antibody serves as a valuable resource for advancing our understanding of biglycan biology and its implications for human health and disease.
Product Name:
BGN Rabbit Polyclonal Antibody
SKU:
CAB5770
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 38-368 of human BGN (NP_001702.1).
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication.
Purification Method:
Affinity purification
Gene ID:
633
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with BGN using BGN Rabbit pAb (CAB5770) at 1:800 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 90s.
