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BID Monoclonal Antibody [P4D3AT] (CPAB0536)

SKU:
CPAB0536
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
P4D3AT
Applications:
WB
ELISA
€149
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Description

system_update_alt Datasheet

BID Monoclonal Antibody [P4D3AT] (CPAB0536)

The BID Antibody (CPAB0536) is a polyclonal antibody designed for research involving the BID protein, a crucial regulator of apoptosis and cell death. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the BID protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for studies in cell biology, cancer research, and apoptosis mechanisms.BID, also known as BH3-interacting domain death agonist, plays a pivotal role in the mitochondrial apoptotic pathway by promoting the release of cytochrome c and initiating apoptosis in response to cell stress signals.

Its involvement in cell death regulation makes it an attractive target for research into diseases like cancer, neurodegenerative disorders, and cardiovascular diseases. Investigating the function of BID is crucial for understanding the mechanisms of cell death and potentially identifying therapeutic interventions that target this pathway.

Product Name:BID Antibody
Product Sku:CPAB0536
Size:5μg
Host Species:Mouse
Immunogen:Anti-human BID mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human BID amino acids 1-195 purified from Ecoli.
Clone:P4D3AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:BID antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:BID accession number NP_001187 is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling, BID interacts with another Bcl-2 family of cell death regulators, called Bax, they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which leads to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1, Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis.
Synonyms:BH3-interacting domain death agonist, p22 BID, BID, FP497, MGC15319, MGC42355.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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