BHRF1 Polyclonal Antibody (PAC061786) is a specialized tool for researchers investigating the BHRF1 protein, a key player in Epstein-Barr virus (EBV) biology. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been rigorously validated for use in Western blot applications. It specifically binds to BHRF1, enabling precise detection and analysis in various cell types, making it an essential tool for studies in virology and cancer research.
BHRF1 is a viral protein encoded by EBV that plays a crucial role in promoting viral replication and immune evasion, making it a critical target for understanding EBV-associated diseases such as lymphomas and nasopharyngeal carcinoma. By uncovering the mechanisms by which BHRF1 functions, researchers can gain valuable insights into the pathogenesis of these diseases and develop novel therapeutic strategies targeting EBV-infected cells.
Antibody Name:
BHRF1 Antibody (PACO61786)
Antibody SKU:
PACO61786
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Epstein-Barr virus
Immunogen:
Recombinant Epstein-Barr virus Apoptosis regulator BHRF1 protein (1-142AA)
Western Blot. Positive WB detected in Recombinant protein. All lanes: BHRF1 antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 18 kDa. Observed band size: 18 kDa.
Background:
Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell.
Synonyms:
Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
UniProt Protein Function:
Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell.
