BHMT2 Antibody (PACO33132)
- SKU:
- PACO33132
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
BHMT2 Antibody (PACO33132)
The BHMT2 Polyclonal Antibody (PACO33132) is a valuable tool for researchers studying BHMT2, a key enzyme involved in the methionine cycle and liver function. The antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. Its ability to specifically bind to the BHMT2 protein allows for precise detection and analysis in a variety of cell types, making it an essential tool for studies in metabolism, liver biology, and potential therapeutic interventions.
BHMT2, also known as betaine-homocysteine methyltransferase 2, plays a crucial role in maintaining methionine levels and methyl group balance in the body. Dysregulation of BHMT2 has been linked to metabolic disorders, liver diseases, and cardiovascular conditions, underscoring its importance in overall health and well-being. By understanding the function and regulation of BHMT2, researchers can explore novel treatment strategies and interventions for conditions related to methionine metabolism and liver health.
| Antibody Name: | BHMT2 Antibody (PACO33132) |
| Antibody SKU: | PACO33132 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human S-methylmethionine--homocysteine S-methyltransferase BHMT2 protein (1-200AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot Positive WB detected in: Mouse liver tissue, Raji whole cell lysate All lanes: BHMT2 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 41, 34 kDa Observed band size: 41, 34 kDa . |
 | Immunofluorescent analysis of Hela cells using PACO33132 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO33132 at dilution of 1:100. |
| Background: | Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. |
| Synonyms: | S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2), BHMT2 |
| UniProt Protein Function: | BHMT2: Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Methyltransferase; EC 2.1.1.10Chromosomal Location of Human Ortholog: 5q13Cellular Component: cytosolMolecular Function: betaine-homocysteine S-methyltransferase activity; homocysteine S-methyltransferase activity; zinc ion bindingBiological Process: methylation; S-methylmethionine cycle; S-methylmethionine metabolic process; S-adenosylmethionine metabolic process; betaine metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010] |
| UniProt Code: | Q9H2M3 |
| NCBI GenInfo Identifier: | 295821189 |
| NCBI Gene ID: | 23743 |
| NCBI Accession: | NP_001171476.1 |
| UniProt Secondary Accession: | Q9H2M3,Q9NXX7, B7Z516 |
| UniProt Related Accession: | Q9H2M3 |
| Molecular Weight: | 40,354 Da |
| NCBI Full Name: | S-methylmethionine--homocysteine S-methyltransferase BHMT2 isoform 2 |
| NCBI Synonym Full Names: | betaine--homocysteine S-methyltransferase 2 |
| NCBI Official Symbol: | BHMT2Â Â |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | S-methylmethionine--homocysteine S-methyltransferase BHMT2; SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2 |
| UniProt Protein Name: | S-methylmethionine--homocysteine S-methyltransferase BHMT2 |
| UniProt Synonym Protein Names: | Betaine--homocysteine S-methyltransferase 2 |
| Protein Family: | S-methylmethionine--homocysteine S-methyltransferase |
| UniProt Gene Name: | BHMT2Â Â |
| UniProt Entry Name: | BHMT2_HUMAN |
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