The BHLHE23 Polyclonal Antibody (PAC064163) is a valuable tool for research involving the BHLHE23 protein, which is known to play a role in various cellular processes, including regulation of gene expression and cellular differentiation. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the BHLHE23 protein, this antibody allows for accurate detection and analysis in a wide range of cell types, making it an ideal choice for studies in developmental biology, cancer research, and other fields.BHLHE23, also referred to as basic helix-loop-helix family member e23, is a transcription factor that has been implicated in the regulation of key genes involved in cell growth, differentiation, and survival.
Its involvement in these processes makes it a promising target for further investigation in the context of developmental disorders, cancer progression, and other diseases. Investigating the function and activity of BHLHE23 with the help of this antibody can provide valuable insights into its role in various physiological and pathological conditions, ultimately contributing to the development of potential therapeutic strategies.
Antibody Name:
BHLHE23 Antibody (PACO64163)
Antibody SKU:
PACO64163
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Class E basic helix-loop-helix protein 23 protein (1-225AA)
IHC image of PACO64163 diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
Background:
May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity).
Synonyms:
Class E basic helix-loop-helix protein 23 (bHLHe23) (Class B basic helix-loop-helix protein 4) (bHLHb4), BHLHE23, BHLHB4
UniProt Protein Function:
BHLHE23: May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation.Protein type: Transcription factorChromosomal Location of Human Ortholog: 20q13.33Cellular Component: nucleusMolecular Function: protein dimerization activity; DNA bindingBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the basic helix-loop-helix transcription factor family. Members of this family contain two highly conserved and functionally distinct domains: the basic domain targets sequence-specific DNA binding, while the helix-loop-helix domain facilitates protein interaction. Studies of a related gene in mouse suggest that the encoded protein may function as a transcriptional repressor in the pancreas and brain, and that it is required for normal retinal function. [provided by RefSeq, May 2013]
