BHLHA15 Antibody (PACO61033)
- SKU:
- PACO61033
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
BHLHA15 Antibody (PACO61033)
The BHLHA15 Polyclonal Antibody (PAC061033) is a valuable tool for researchers studying BHLHA15, a transcription factor known to regulate gene expression in various biological processes. This antibody, developed in rabbits, exhibits high specificity and sensitivity towards human BHLHA15 proteins, allowing for precise detection in Western blot experiments.BHLHA15, also known as class E basic helix-loop-helix protein 15, plays a crucial role in cellular differentiation and development, making it a key target for investigations in developmental biology and cancer research.
By targeting BHLHA15, researchers can unravel its functions in gene regulation and potentially uncover new therapeutic strategies for manipulating cellular processes.With its proven performance in detecting BHLHA15, the PAC061033 antibody is a reliable tool for scientists exploring the biological functions and regulatory mechanisms of this transcription factor. Its use in research may lead to advancements in understanding cellular pathways and developing targeted therapies for various diseases.
| Antibody Name: | BHLHA15 Antibody (PACO61033) |
| Antibody SKU: | PACO61033 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Class A basic helix-loop-helix protein 15 protein (2-72AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO61033 diluted at 1:150 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity). |
| Synonyms: | Class A basic helix-loop-helix protein 15 (bHLHa15) (Class B basic helix-loop-helix protein 8) (bHLHb8) (Muscle, intestine and stomach expression 1) (MIST-1), BHLHA15, BHLHB8 MIST1 |
| UniProt Protein Function: | MIST1: Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3'.Chromosomal Location of Human Ortholog: 7q21.3Cellular Component: nucleusMolecular Function: protein homodimerization activityBiological Process: G-protein coupled receptor protein signaling pathway; cellular response to glucose starvation; transcription, DNA-dependent; cell-cell signaling; unfolded protein response; cell maturation; intracellular distribution of mitochondria; calcium-mediated signaling; positive regulation of transcription from RNA polymerase II promoter; glucose homeostasis; Golgi organization and biogenesis; mitochondrial calcium ion transport |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q7RTS1 |
| NCBI GenInfo Identifier: | 29126247 |
| NCBI Gene ID: | 168620 |
| NCBI Accession: | NP_803238.1 |
| UniProt Secondary Accession: | Q7RTS1,Q14DE4, A4D271 |
| UniProt Related Accession: | Q7RTS1 |
| Molecular Weight: | 20,818 Da |
| NCBI Full Name: | class A basic helix-loop-helix protein 15 |
| NCBI Synonym Full Names: | basic helix-loop-helix family, member a15 |
| NCBI Official Symbol: | BHLHA15Â Â |
| NCBI Official Synonym Symbols: | MIST1; BHLHB8Â Â |
| NCBI Protein Information: | class A basic helix-loop-helix protein 15; MIST-1; class II bHLH protein MIST1; class B basic helix-loop-helix protein 8; muscle, intestine and stomach expression 1; basic helix-loop-helix domain containing, class B, 8 |
| UniProt Protein Name: | Class A basic helix-loop-helix protein 15 |
| UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 8; bHLHb8; Muscle, intestine and stomach expression 1; MIST-1 |
| Protein Family: | Class A basic helix-loop-helix protein |
| UniProt Gene Name: | BHLHA15Â Â |
| UniProt Entry Name: | BHA15_HUMAN |
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