UniProt Protein Function: | MIST1: Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3'.Chromosomal Location of Human Ortholog: 7q21.3Cellular Component: nucleusMolecular Function: protein homodimerization activityBiological Process: G-protein coupled receptor protein signaling pathway; cellular response to glucose starvation; transcription, DNA-dependent; cell-cell signaling; unfolded protein response; cell maturation; intracellular distribution of mitochondria; calcium-mediated signaling; positive regulation of transcription from RNA polymerase II promoter; glucose homeostasis; Golgi organization and biogenesis; mitochondrial calcium ion transport |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q7RTS1 |
NCBI GenInfo Identifier: | 29126247 |
NCBI Gene ID: | 168620 |
NCBI Accession: | NP_803238.1 |
UniProt Secondary Accession: | Q7RTS1,Q14DE4, A4D271 |
UniProt Related Accession: | Q7RTS1 |
Molecular Weight: | 20,818 Da |
NCBI Full Name: | class A basic helix-loop-helix protein 15 |
NCBI Synonym Full Names: | basic helix-loop-helix family, member a15 |
NCBI Official Symbol: | BHLHA15Â Â |
NCBI Official Synonym Symbols: | MIST1; BHLHB8Â Â |
NCBI Protein Information: | class A basic helix-loop-helix protein 15; MIST-1; class II bHLH protein MIST1; class B basic helix-loop-helix protein 8; muscle, intestine and stomach expression 1; basic helix-loop-helix domain containing, class B, 8 |
UniProt Protein Name: | Class A basic helix-loop-helix protein 15 |
UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 8; bHLHb8; Muscle, intestine and stomach expression 1; MIST-1 |
Protein Family: | Class A basic helix-loop-helix protein |
UniProt Gene Name: | BHLHA15Â Â |
UniProt Entry Name: | BHA15_HUMAN |