The BGLAP Polyclonal Antibody (CAB18241) is a valuable tool for researchers studying Bone Gamma Carboxyglutamate Protein (BGLAP), also known as Osteocalcin. This antibody, generated in rabbits, is highly specific to human samples and is validated for use in various applications, including Western blotting.BGLAP is a key protein in bone formation and mineralization, making it essential for studying bone metabolism and diseases such as osteoporosis. The BGLAP Polyclonal Antibody binds specifically to the BGLAP protein, allowing for accurate detection and analysis in a variety of cell types.
Research involving BGLAP can provide insights into bone health, bone turnover, and potential therapeutic targets for bone-related disorders. By understanding the role of BGLAP in bone physiology, researchers can develop new strategies for diagnosing and treating skeletal diseases. The BGLAP Polyclonal Antibody is a valuable resource for scientists interested in advancing their studies in bone biology and related fields.
Product Name:
BGLAP Rabbit Polyclonal Antibody
SKU:
CAB18241
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-95 of human Osteocalcin (BGLAP) (NP_954642.1).
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product.
Purification Method:
Affinity purification
Gene ID:
632
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Osteocalcin (BGLAP) antibody (CAB18241) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
