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Bglap Antibody (PACO25252)

SKU:
PACO25252
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407
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Description

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Bglap Antibody (PACO25252)

The BGLAP Antibody (PAC025252) is a high-quality polyclonal antibody designed for research involving the Bone Gamma-Carboxyglutamic Acid-Containing Protein (BGLAP). This protein, also known as Osteocalcin, is a key marker of bone formation and mineralization.Raised in rabbits, this antibody is highly specific and reactive with human samples, making it ideal for use in various research applications. It is validated for use in techniques such as Western blotting, immunohistochemistry, and flow cytometry, allowing for accurate detection and analysis of BGLAP in different cell types and tissues.

BGLAP plays a crucial role in bone metabolism and is associated with various bone-related disorders, including osteoporosis and osteogenesis imperfecta. By studying the expression and function of BGLAP, researchers can gain valuable insights into the mechanisms of bone formation and mineralization, as well as potential therapeutic targets for treating bone diseases.Overall, the BGLAP Antibody (PAC025252) offers researchers a reliable tool for investigating the role of BGLAP in bone biology and pathology, ultimately contributing to advances in the field of skeletal research.

Antibody Name:Bglap Antibody (PACO25252)
Antibody SKU:PACO25252
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Rat
Immunogen:Recombinant Rat Osteocalcin protein (50-99AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
Synonyms:Osteocalcin (Bone Gla protein) (BGP) (Gamma-carboxyglutamic acid, containing protein), Bglap, Bglap2
UniProt Protein Function:osteocalcin: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Belongs to the osteocalcin/matrix Gla protein family.
UniProt Protein Details:

Protein type:Cell development/differentiation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q34

Cellular Component: cell projection; cytoplasm; dendrite; extracellular region; extracellular space; Golgi apparatus; perikaryon; rough endoplasmic reticulum; vesicle

Molecular Function:calcium ion binding; structural constituent of bone

Biological Process: aging; biomineral formation; cell aging; odontogenesis; ossification; osteoblast development; osteoblast differentiation; regulation of bone mineralization; response to activity; response to drug; response to estrogen; response to ethanol; response to glucocorticoid stimulus; response to gravity; response to hydroxyisoflavone; response to inorganic substance; response to mechanical stimulus; response to nutrient levels; response to organic cyclic compound; response to testosterone stimulus; response to vitamin D; response to vitamin K; response to zinc ion

NCBI Summary:highly conserved protein associated with mineralized bone matrix; protein is secreted by calcified tissues and is regulated by vitamin D3 [RGD, Feb 2006]
UniProt Code:P04640
NCBI GenInfo Identifier:11761543
NCBI Gene ID:25295
NCBI Accession:NP_038200.1
UniProt Related Accession:P04640
Molecular Weight:10,927 Da
NCBI Full Name:osteocalcin preproprotein
NCBI Synonym Full Names:bone gamma-carboxyglutamate protein
NCBI Official Symbol:Bglap  
NCBI Official Synonym Symbols:Bgp; Bgpr; Bgpra; Bglap2  
NCBI Protein Information:osteocalcin
UniProt Protein Name:Osteocalcin
UniProt Synonym Protein Names:Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein
UniProt Gene Name:Bglap  

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