Anti-betaIII Tubulin Antibody (AGIM0122)

betaIII Tubulin monoclonal antibody (AGIM0122)

SKU:

AGIM0122

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Host Species:

Mouse

Isotype:

IgG1

Clone:

TU20

Conjugation:

Unconjugated

Applications:

Description

Description

Datasheet

Isotype:	IgG1
Host Species:	Mouse
Storage:	Store at 2 - 8°C. Do not freeze!
Uniprot:	Q13509
Background:	The betaIII-tubulin isoform is present dominantly in cells of neuronal origin and it is one of the earliest markers of neuronal differentiation. It is regarded as a specific probe for the cells of neuronal origin as well as for the tumours originating from these cells. The betaIII-tubulin is most abundant in cells of neuronal origin, but was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues.

UniProt Protein Function:	TUBB3: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Dimer of alpha and beta chains. Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. Belongs to the tubulin family.
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 16q24.3 Cellular Component: axon; cell soma; cytoplasm; dendrite; microtubule; nucleus Molecular Function:GTP binding; GTPase activity; peptide binding; protein binding; structural constituent of cytoskeleton Biological Process: 'de novo' posttranslational protein folding; axon guidance; cellular protein metabolic process; microtubule-based process; mitosis; protein folding Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 1; Fibrosis Of Extraocular Muscles, Congenital, 3a, With Or Without Extraocular Involvement
NCBI Summary:	This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]
UniProt Code:	Q13509
NCBI GenInfo Identifier:	20455526
NCBI Gene ID:	10381
NCBI Accession:	Q13509.2
UniProt Secondary Accession:	Q13509,Q9BTZ0, Q9BW10, A8K854,
UniProt Related Accession:	Q13509
Molecular Weight:	42,433 Da
NCBI Full Name:	Tubulin beta-3 chain
NCBI Synonym Full Names:	tubulin beta 3 class III
NCBI Official Symbol:	TUBB3
NCBI Official Synonym Symbols:	CDCBM; FEOM3; TUBB4; CDCBM1; CFEOM3; beta-4; CFEOM3A
NCBI Protein Information:	tubulin beta-3 chain
UniProt Protein Name:	Tubulin beta-3 chain
UniProt Synonym Protein Names:	Tubulin beta-4 chain; Tubulin beta-III
Protein Family:	Tubulin
UniProt Gene Name:	TUBB3
UniProt Entry Name:	TBB3_HUMAN