The Beta-Synuclein Polyclonal Antibody (CAB10443) is a valuable tool for researchers studying beta-synuclein, a protein associated with neurodegenerative diseases like Parkinson's and Alzheimer's. This antibody, generated in rabbits, has high specificity for human samples and is validated for use in Western blot applications. By targeting the beta-synuclein protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for studies in neuroscience and neurodegenerative diseases.Beta-synuclein is known to play a role in regulating neurotransmitter release and synaptic function in the brain.
Dysregulation of beta-synuclein has been linked to the pathogenesis of neurodegenerative disorders, making it a promising target for therapeutic interventions. Investigating the function of beta-synuclein with this antibody may offer insights into the underlying mechanisms of these diseases and lead to the development of novel treatment strategies.Overall, the Beta-Synuclein Polyclonal Antibody (CAB10443) provides researchers with a valuable tool for studying the role of beta-synuclein in neurodegenerative diseases and advancing our understanding of potential therapeutic targets in this field.
Product Name:
β-Synuclein Rabbit Polyclonal Antibody
SKU:
CAB10443
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-134 of human β-Synuclein (NP_001001502.1).
This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6620
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using β-Synuclein antibody (CAB10443) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
