The Beta-Secretase-1 Polyclonal Antibody (CAB5266) is a valuable tool for researchers studying the Beta-Secretase-1 enzyme, which plays a key role in the processing of amyloid precursor protein (APP) and the pathogenesis of Alzheimer's disease. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.Beta-Secretase-1, also known as BACE1, is a critical enzyme involved in the production of amyloid-beta peptides, which form the amyloid plaques found in the brains of Alzheimer's patients.
By targeting BACE1 with this antibody, researchers can detect and analyze the activity of this enzyme in various cell types, providing important insights into the mechanisms of Alzheimer's disease.The Beta-Secretase-1 Polyclonal Antibody is a valuable tool for researchers investigating the role of BACE1 in Alzheimer's disease and other neurodegenerative disorders. By better understanding the activity of this enzyme, researchers can develop new therapies and interventions to target BACE1 and potentially slow or prevent the progression of Alzheimer's disease.
Product Name:
BACE1 Rabbit Polyclonal Antibody
SKU:
CAB5266
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-322 of human BACE1 (NP_036236.1).
Cell surface, Cytoplasmic vesicle membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Single-pass type I membrane protein, trans-Golgi network.
Calculated MW:
56kDa
Observed MW:
70kDa
This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients.
Purification Method:
Affinity purification
Gene ID:
23621
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from SH-SY5Y cells, using BACE1 Rabbit pAb (CAB5266) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
