BACE1 Rabbit Polyclonal Antibody (CAB5266)
- SKU:
- CAB5266
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | BACE1 Rabbit Polyclonal Antibody |
SKU: | CAB5266 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-322 of human BACE1 (NP_036236.1). |
Sequence: | TQHG IRLP LRSG LGGA PLGL RLPR ETDE EPEE PGRR GSFV EMVD NLRG KSGQ GYYV EMTV GSPP QTLN ILVD TGSS NFAV GAAP HPFL HRYY QRQL SSTY RDLR KGVY VPYT QGKW EGEL GTDL VSIP HGPN VTVR ANIA AITE SDKF FING SNWE GILG LAYA EIAR PDDS LEPF FDSL VKQT HVPN LFSL QLCG AGFP LNQS EVLA SVGG SMII GGID HSLY TGSL WYTP IRRE WYYE VIIV RVEI NGQD LKMD CKEY NYDK SIVD SGTT NLRL PKKV FEAA VKSI KAAS STEK FPDG F |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | ASP2; BACE; HSPC104; BACE1 |
Positive Sample: | SH-SY5Y |
Conjugate: | Unconjugated |
Cellular Localization: | Cell surface, Cytoplasmic vesicle membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Single-pass type I membrane protein, trans-Golgi network. |
Calculated MW: | 56kDa |
Observed MW: | 70kDa |
This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients.
Purification Method: | Affinity purification |
Gene ID: | 23621 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |