ARRB1 Rabbit Polyclonal Antibody (CAB0998)
- SKU:
- CAB0998
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | ARRB1 Rabbit Polyclonal Antibody |
SKU: | CAB0998 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 169-418 of human β-arrestin1 (NP_004032.2). |
Sequence: | RKVQ YAPE RPGP QPTA ETTR QFLM SDKP LHLE ASLD KEIY YHGE PISV NVHV TNNT NKTV KKIK ISVR QYAD ICLF NTAQ YKCP VAME EADD TVAP SSTF CKVY TLTP FLAN NREK RGLA LDGK LKHE DTNL ASST LLRE GANR EILG IIVS YKVK VKLV VSRG GLLG DLAS SDVA VELP FTLM HPKP KEEP PHRE VPEN ETPV DTNL IELD TNDD DIVF EDFA RQRL KGMK DDKE EEED GTGS PQLN NR |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | ARB1; ARR1; β-arrestin1 |
Positive Sample: | K-562,A-549,Mouse lung,Rat lung,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus, clathrin-coated pit, pseudopodium. |
Calculated MW: | 47kDa |
Observed MW: | 51kDa |
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.
Purification Method: | Affinity purification |
Gene ID: | 408 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |