The Beta-Arrestin-1 Monoclonal Antibody (CAB10742) is a valuable tool for researchers studying the role of beta-arrestin-1 in cellular signaling pathways. This antibody, produced using advanced monoclonal antibody technology, specifically targets beta-arrestin-1, a key protein involved in G protein-coupled receptor (GPCR) signaling and regulation.Beta-arrestin-1 has been implicated in various physiological processes, including cell migration, proliferation, and apoptosis, making it a promising target for therapeutic interventions in diseases such as cancer and cardiovascular disorders. With its high specificity and sensitivity, the Beta-Arrestin-1 Monoclonal Antibody is ideal for use in Western blotting, immunofluorescence, and immunoprecipitation assays to detect and quantify beta-arrestin-1 levels in different cell types and tissues.
By using this antibody, researchers can gain valuable insights into the mechanisms underlying beta-arrestin-1-mediated signaling pathways and their potential implications in disease pathology. This versatile tool opens up new possibilities for investigating the role of beta-arrestin-1 in various biological processes and paving the way for the development of novel therapeutic strategies.
Product Name:
ARRB1 Rabbit Monoclonal Antibody
SKU:
CAB10742
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human β-arrestin1 (P49407).
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.
Purification Method:
Affinity purification
Gene ID:
408
Clone Number:
ARC2370
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using β-arrestin1 Rabbit mAb (CAB10742) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
