BEST1 Rabbit Polyclonal Antibody (CAB3022)
- SKU:
- CAB3022
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Product Name: | BEST1 Rabbit Polyclonal Antibody |
SKU: | CAB3022 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 171-270 of human BEST1 (NP_004174.1). |
Sequence: | LEKL SLPH NMFW VPWV WFAN LSMK AWLG GRIR DPIL LQSL LNEM NTLR TQCG HLYA YDWI SIPL VYTQ VVTV AVYS FFLT CLVG RQFL NPAK AYPG HELD |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ARB; BMD; BEST; RP50; VMD2; TU15B; Best1V1Delta2; BEST1 |
Positive Sample: | 293T,Mouse testis,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Basolateral cell membrane, Cell membrane, Multi-pass membrane protein. |
Calculated MW: | 68kDa |
Observed MW: | 70kDa |
This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
Purification Method: | Affinity purification |
Gene ID: | 7439 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |