The BEST3 Polyclonal Antibody (PACO08005) is a valuable tool for researchers studying BEST3, a key protein involved in ion transport and regulation of cellular processes. This polyclonal antibody, developed using high-quality rabbit immunogens, exhibits strong reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the BEST3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in areas such as physiology, pharmacology, and cell biology.BEST3, also known as Bile salt export pump 2 or ATP-binding cassette sub-family B member 3, plays an essential role in maintaining cellular homeostasis by transporting bile salts and other substrates across cell membranes.
Dysregulation of BEST3 function has been implicated in various diseases, including cholestasis and liver disorders. Therefore, understanding the mechanisms underlying BEST3 activity is crucial for developing targeted therapies and interventions for such conditions.Overall, the BEST3 Polyclonal Antibody (PACO08005) offers researchers a reliable tool for studying the function and regulation of BEST3 in both normal physiology and disease states. Its high specificity and sensitivity make it a valuable asset for research in the fields of hepatology, gastroenterology, and drug discovery.
VMD2L3: Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Belongs to the bestrophin family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integralChromosomal Location of Human Ortholog: 12q15Cellular Component: integral to plasma membraneMolecular Function: chloride channel activityBiological Process: negative regulation of ion transport
UniProt Protein Details:
NCBI Summary:
BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008]
