The Best2 Antibody (PACO07013) is a polyclonal antibody specifically designed for research involving CD300A, a key cell surface molecule implicated in immune regulation. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the CD300A protein, this antibody enables detection and analysis in various cell types, making it an ideal tool for studies in immunology and cancer research.CD300A, also known as an immune inhibitory receptor, plays a crucial role in immune homeostasis by regulating inflammation and inhibiting allergic reactions.
Its significance in modulating immune responses makes it a valuable target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the activity of CD300A is vital for the development of therapies that harness or modulate immune function in these contexts.Overall, the Best2 Antibody (PACO07013) offers researchers a high-quality tool for studying CD300A and its role in immune regulation, providing valuable insights into various disease states and potential therapeutic targets.
Antibody Name:
BEST2 Antibody (PACO07013)
Antibody SKU:
PACO07013
Size:
50ug
Host Species:
Rabbit
Tested Applications:
WB, IHC
Recommended Dilutions:
WB:1:500-1:1000, IHC:1:200-1:500
Species Reactivity:
Mouse, Rat
Immunogen:
Synthetic Peptide
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:
Affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of 1) Mouse Brain Tissue, 2) Rat Brain Tissue using BEST2 Polyclonal Antibody.
Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using BEST2 Polyclonal Antibody.
Synonyms:
Bestrophin-2
UniProt Protein Function:
BEST2: Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Belongs to the bestrophin family.Protein type: Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral; TransporterChromosomal Location of Human Ortholog: 19p13.2Cellular Component: cilium; integral to plasma membraneMolecular Function: chloride channel activityBiological Process: membrane depolarization; sensory perception of smell
UniProt Protein Details:
NCBI Summary:
This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. [provided by RefSeq, Jul 2008]
