BEST1 Rabbit Polyclonal Antibody (CAB14070)
- SKU:
- CAB14070
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Product Name: | BEST1 Rabbit Polyclonal Antibody |
SKU: | CAB14070 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 376-585 of human BEST1 (NP_004174.1). |
Sequence: | QPNQ EDEE DAHA GIIG RFLG LQSH DHHP PRAN SRTK LLWP KRES LLHE GLPK NHKA AKQN VRGQ EDNK AWKL KAVD AFKS APLY QRPG YYSA PQTP LSPT PMFF PLEP SAPS KLHS VTGI DTKD KSLK TVSS GAKK SFEL LSES DGAL MEHP EVSQ VRRK TVEF NLTD MPEI PENH LKEP LEQS PTNI HTTL KDHM DPYW ALEN RDEA HS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ARB; BMD; BEST; RP50; VMD2; TU15B; Best1V1Delta2; BEST1 |
Positive Sample: | Mouse liver,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Basolateral cell membrane, Cell membrane, Multi-pass membrane protein. |
Calculated MW: | 68kDa |
Observed MW: | 68kDa |
This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
Purification Method: | Affinity purification |
Gene ID: | 7439 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |