The BECN1 Polyclonal Antibody (CAB17028) is specially designed for research involving BECN1, a key regulator of autophagy and cellular homeostasis. This antibody, derived from rabbits, exhibits high reactivity with human samples and has been extensively validated for use in Western blot applications. It specifically binds to the BECN1 protein, enabling precise detection and analysis in a variety of cell types.BECN1, also known as Beclin 1, is a critical player in the autophagy pathway, which is responsible for degrading and recycling cellular components to maintain cellular health and function. Dysregulation of autophagy has been implicated in various diseases, including cancer, neurodegenerative disorders, and infectious diseases.
Therefore, research into the function and regulation of BECN1 is essential for understanding these disease processes and developing potential therapeutic interventions.By using the BECN1 Polyclonal Antibody in your experiments, you can uncover valuable insights into the role of BECN1 in autophagy and its implications for disease pathology. Whether studying cancer biology, neurodegeneration, or infectious disease mechanisms, this antibody is a valuable tool for advancing your research in cellular homeostasis and potential therapeutic targets.
Product Name:
Beclin 1 Rabbit Polyclonal Antibody
SKU:
CAB17028
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-280 of human Beclin 1 (NP_003757.1).
This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8678
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Beclin 1 Rabbit pAb (CAB17028) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
