The BDNF Polyclonal Antibody (CAB16299) is a valuable tool for researchers studying brain-derived neurotrophic factor (BDNF), a protein essential for neuronal growth and survival in the central nervous system. This antibody, raised in rabbits, exhibits high reactivity with human samples and is optimized for use in Western blot applications. By specifically binding to BDNF, researchers can accurately detect and analyze levels of this important neurotrophic factor in various cell types.
BDNF is known for its role in promoting neuronal plasticity, synaptic transmission, and overall cognitive function. Dysregulation of BDNF has been implicated in a range of neurological disorders, including depression, Alzheimer's disease, and Parkinson's disease. By studying BDNF expression and activity using the CAB16299 antibody, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.
Product Name:
BDNF Rabbit Polyclonal Antibody
SKU:
CAB16299
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-247 of human BDNF (NP_733928.1).
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders.
Purification Method:
Affinity purification
Gene ID:
627
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using BDNF Rabbit pAb (CAB16299) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
