The BDNF Polyclonal Antibody (CAB1307) is a specialized research tool designed for studying brain-derived neurotrophic factor (BDNF), a key protein involved in neuronal development and plasticity. This antibody, produced in rabbits, is highly specific to BDNF in human samples and is validated for use in Western blot applications. By binding to the BDNF protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential tool for studies in neuroscience and neurodegenerative diseases.BDNF is a crucial factor in promoting neuronal survival, growth, and function in the brain, making it a central focus in understanding conditions such as Alzheimer's disease, depression, and neurodevelopmental disorders.
The role of BDNF in synaptic plasticity and cognitive function highlights its potential as a therapeutic target for promoting brain health and treating neurological disorders. Utilizing the BDNF Polyclonal Antibody is essential for advancing research in these areas and developing targeted interventions to improve brain function and well-being.
Product Name:
BDNF Rabbit Polyclonal Antibody
SKU:
CAB1307
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-247 of human BDNF (NP_733928.1).
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders.
Purification Method:
Affinity purification
Gene ID:
627
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using BDNF Rabbit pAb (CAB1307) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
