The BCR Polyclonal Antibody (CAB0068) is a valuable tool for researchers studying BCR, a key protein involved in B cell receptor signaling. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the BCR protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in immunology and cancer research.
BCR, also known as B-cell receptor, is essential for B cell activation and plays a crucial role in immune response modulation. Understanding the function of BCR is important for unraveling the mechanisms underlying diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By studying the activity of BCR, researchers can develop targeted therapies that manipulate B cell signaling pathways to effectively treat these diseases.
Product Name:
BCR Rabbit Polyclonal Antibody
SKU:
CAB0068
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human BCR (NP_004318.3).
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
613
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using BCR Rabbit pAb (CAB0068) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
