BCR Rabbit Polyclonal Antibody (CAB0068)
- SKU:
- CAB0068
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | BCR Rabbit Polyclonal Antibody |
SKU: | CAB0068 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human BCR (NP_004318.3). |
Sequence: | MVDP VGFA EAWK AQFP DSEP PRME LRSV GDIE QELE RCKA SIRR LEQE VNQE RFRM IYLQ TLLA KEKK SYDR QRWG FRRA AQAP DGAS EPRA SASR PQPA PADG ADPP PAEE PEAR PDGE GSPG KARP GTAR RPGA AASG ERDD RGPP ASVA ALRS NFER IRKG HGQP GADA EKPF YVNV EFHH ERGL VKVN DKEV SDRI SSLG SQAM QMER KKSQ HGAG SSVG DASR PPYR GRSS ESSC GVDG DYED AELN PRFL KDNL IDAN GGSR PPWP PLEY QPYQ SIYV GGMM EGEG KGPL LRSQ |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 |
Synonyms: | ALL; CML; PHL; BCR1; D22S11; D22S662; BCR |
Positive Sample: | 293T,Jurkat,HeLa,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, postsynaptic cell membrane, postsynaptic density, synapse. |
Calculated MW: | 143kDa |
Observed MW: | 150kDa |
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 613 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |