The BCL7A Polyclonal Antibody (PAC004927) is a valuable tool for researchers investigating the BCL7A protein, which plays a key role in chromosomal translocations associated with B cell lymphoma. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the BCL7A protein, this antibody enables accurate detection and analysis in a variety of cell types, making it well-suited for studies in oncology and hematological malignancies.
BCL7A is a component of the BCLAF1 complex involved in transcriptional regulation, cell cycle control, and apoptosis. Dysregulation of BCL7A expression has been linked to the development and progression of various cancers, making it a promising target for therapeutic intervention. Understanding the function of BCL7A is essential for advancing research in cancer biology and developing targeted treatments for malignancies associated with B cell lymphoma.
Antibody Name:
BCL7A Antibody
Antibody SKU:
PACO04927
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human Bcl-7a.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
BCL7A; B-cell CLL/lymphoma 7 protein family member A
UniProt Protein Function:
Bcl-7A: Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions. Belongs to the BCL7 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Actin-bindingChromosomal Location of Human Ortholog: 12q24.13Molecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
