The BCL3 Polyclonal Antibody (CAB11582) is a valuable tool for researchers studying the BCL3 protein, a key regulator of immune responses and inflammation. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the BCL3 protein, this antibody enables precise detection and analysis in various cell types, making it an essential component for studies in immunology and cancer research.
BCL3, also known as B-cell CLL/lymphoma 3, is a critical modulator of immune and inflammatory responses, playing a crucial role in the regulation of gene expression and cell proliferation. Its involvement in these processes makes it an attractive target for research on diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the function of BCL3 is essential for the development of therapies that target immune dysregulation in these disease contexts.
Product Name:
BCL3 Rabbit Polyclonal Antibody
SKU:
CAB11582
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human BCL3 (NP_005169.2).
Sequence:
ANVN AQMY SGSS ALHS ASGR GLLP LVRT LVRS GADS SLKN CHND TPLM VARS RRVI DILR GKAT RPAS TSQP DPSP DRSA NTSP ESSS RLSS NGLL SASP S
Tested Applications:
WBIF/ICCELISA
Recommended Dilution:
WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200
Synonyms:
BCL4; D19S37; BCL3
Positive Sample:
Raji,293T
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus, perinuclear region.
Calculated MW:
48kDa
Observed MW:
60kDa
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.
Purification Method:
Affinity purification
Gene ID:
602
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using BCL3 Rabbit pAb (CAB11582) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
