The BCL2L2 Polyclonal Antibody (CAB1158) is a valuable tool for researchers studying BCL2L2, a key regulator of apoptosis and cell survival. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the BCL2L2 protein, this antibody enables the detection and analysis of BCL2L2 in various cell types.BCL2L2, also known as Bcl-w, plays a crucial role in the regulation of programmed cell death, particularly in maintaining cell survival and preventing apoptosis. Its involvement in these pathways makes it a target of interest in cancer research, as dysregulation of apoptosis is a common feature of many cancers.
Research into BCL2L2 function is essential for understanding its role in cancer development and progression, as well as for identifying potential therapeutic targets for cancer treatment.Overall, the BCL2L2 Polyclonal Antibody is a valuable research tool for investigating the role of BCL2L2 in cellular signaling pathways, particularly in the context of cancer biology. Its high specificity and sensitivity make it ideal for studying the functions of BCL2L2 in various biological systems.
Product Name:
Bcl-W Rabbit Polyclonal Antibody
SKU:
CAB1158
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-193 of human Bcl-W (NP_004041.2).
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
Purification Method:
Affinity purification
Gene ID:
599
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Bcl-W antibody (CAB1158) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
