The BCL2L11 Polyclonal Antibody (CAB15771) is a valuable tool for researchers studying BCL2L11, a protein involved in regulating apoptosis, or programmed cell death. This antibody is produced in rabbits and is highly reactive with human samples, making it suitable for use in Western blot applications for the detection and analysis of BCL2L11 in various cell types.BCL2L11, also known as Bim, is a key player in the intrinsic apoptosis pathway, which is essential for the maintenance of tissue homeostasis and removal of damaged or unwanted cells. Dysregulation of BCL2L11 has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions.
Therefore, understanding the role of BCL2L11 in apoptosis regulation is crucial for developing targeted therapies for these diseases.By utilizing the BCL2L11 Polyclonal Antibody, researchers can explore the mechanisms underlying BCL2L11-mediated apoptosis and its potential therapeutic implications. This antibody provides a reliable tool for studying BCL2L11 in both basic research and drug development efforts aimed at manipulating apoptosis for therapeutic benefit.
Product Name:
Bim Rabbit Polyclonal Antibody
SKU:
CAB15771
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-198 of human Bim (NP_619527.1).
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
Purification Method:
Affinity purification
Gene ID:
10018
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Bim antibody (CAB15771) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
