The BCL2 Isoform Beta Polyclonal Antibody (CAB18415) is a valuable tool for researchers studying the BCL2 protein, specifically the beta isoform, which plays a critical role in apoptosis and cell survival. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.The BCL2 protein family is known for its involvement in regulating apoptosis, with the beta isoform specifically implicated in promoting cell survival by inhibiting apoptosis. Dysregulation of BCL2 isoform beta has been linked to various diseases, including cancer and autoimmune disorders, making it a target of interest for researchers in the fields of oncology and immunology.
By utilizing the BCL2 Isoform Beta Polyclonal Antibody, researchers can accurately detect and analyze the expression of BCL2 isoform beta in various cell types, providing valuable insights into its role in cell survival and potential therapeutic targeting. This antibody is a valuable tool for advancing research in apoptosis regulation and cellular responses to stress and treatment.
Product Name:
Bcl2(Isoform Beta) Rabbit Polyclonal Antibody
SKU:
CAB18415
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-199 of mouse Bcl2(Isoform Beta) (NP_803129.2).
cytoplasm, cytosol, endoplasmic reticulum, mitochondrial crista, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, nuclear membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm
Calculated MW:
26kDa
Observed MW:
22kDa
This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and autophagy. Abnormal expression and chromosomal translocations of this gene are associated with cancer progression in numerous tissues. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
12043
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat liver, using Bcl2(Isoform Beta) Rabbit pAb (CAB18415) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
