Anti-CTIP1 Antibody (CAB9231)
- SKU:
- CAB9231
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Anti-CTIP1 Antibody (CAB9231)
The CTIP1 Rabbit Monoclonal Antibody (CAB9231) is a powerful tool for researchers studying CTIP1, a transcriptional repressor involved in various cellular processes, including DNA repair and apoptosis. This antibody, developed using innovative technology, delivers high specificity and sensitivity in detecting CTIP1 in human samples. Validated for use in Western blot and immunofluorescence applications, this antibody enables precise visualization and analysis of CTIP1 expression in different cell types.CTIP1, also known as RBBP8, is crucial for maintaining genomic stability and regulating gene expression.
Dysregulation of CTIP1 has been implicated in cancer development and progression, making it a promising target for cancer research. By understanding the role of CTIP1 in DNA repair mechanisms and cell survival, researchers can uncover potential therapeutic strategies for treating cancer and other genetic disorders.Overall, the CTIP1 Rabbit Monoclonal Antibody (CAB9231) provides a valuable tool for investigating the function and regulation of CTIP1 in various biological processes, offering new insights into its potential role in disease pathogenesis and therapeutic interventions.
| Antibody Name: | Anti-CTIP1 Antibody |
| Antibody SKU: | CAB9231 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CTIP1 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat brain |
| Immunogen: | A synthesized peptide derived from human CTIP1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 53335 |
| Uniprot: | Q9H165 |
| Cellular Location: | |
| Calculated MW: | 120kDa |
| Observed MW: | 100KDa |
| Synonyms: | BCL11A-L, BCL11A-S, BCL11A-XL, BCL11a-M, CTIP1, DILOS, EVI9, HBFQTL5, ZNF856 |
| Background: | This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | Bcl-11A: Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and amplification. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; C2H2-type zinc finger protein; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 2p16.1 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:protein homodimerization activity; protein heterodimerization activity; metal ion binding; transcription corepressor activity Biological Process: protein sumoylation; transcription, DNA-dependent; B cell differentiation; regulation of dendrite development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of collateral sprouting; negative regulation of transcription from RNA polymerase II promoter; negative regulation of axon extension; positive regulation of collateral sprouting; negative regulation of protein homooligomerization; T cell differentiation |
| NCBI Summary: | This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H165 |
| NCBI GenInfo Identifier: | 20336307 |
| NCBI Gene ID: | 53335 |
| NCBI Accession: | NP_060484.2 |
| UniProt Secondary Accession: | Q9H165,Q86W14, Q8WU92, Q96JL6, Q9H163, Q9H164, Q9H3G9 Q9NWA7, D6W5D7, |
| UniProt Related Accession: | Q9H165 |
| Molecular Weight: | 91,197 Da |
| NCBI Full Name: | B-cell lymphoma/leukemia 11A isoform 2 |
| NCBI Synonym Full Names: | B-cell CLL/lymphoma 11A (zinc finger protein) |
| NCBI Official Symbol: | BCL11AÂ Â |
| NCBI Official Synonym Symbols: | EVI9; CTIP1; ZNF856; HBFQTL5; BCL11A-L; BCL11A-S; BCL11a-M; BCL11A-XLÂ Â |
| NCBI Protein Information: | B-cell lymphoma/leukemia 11A; EVI-9; BCL-11A; zinc finger protein 856; C2H2-type zinc finger protein; COUP-TF-interacting protein 1; ecotropic viral integration site 9 homolog; ecotropic viral integration site 9 protein homolog; B-cell CLL/lymphoma 11A (z |
| UniProt Protein Name: | B-cell lymphoma/leukemia 11A |
| UniProt Synonym Protein Names: | B-cell CLL/lymphoma 11A; COUP-TF-interacting protein 1; Ecotropic viral integration site 9 protein homolog; EVI-9; Zinc finger protein 856 |
| Protein Family: | B-cell lymphoma/leukemia |
| UniProt Gene Name: | BCL11AÂ Â |
| UniProt Entry Name: | BC11A_HUMAN |
 | Western blot - CTIP1 Rabbit mAb (CAB9231) |
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