Bcl10 Polyclonal Antibody (CAB0191)
- SKU:
- CAB0191
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | Bcl10 Polyclonal Antibody |
SKU: | CAB0191 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human Bcl10 (NP_003912.1). |
Sequence: | MEPT APSL TEED LTEV KKDA LENL RVYL CEKI IAER HFDH LRAK KILS REDT EEIS CRTS SRKR AGKL LDYL QENP KGLD TLVE SIRR EKTQ NFLI QKIT DEVL KLRN IKLE HLKG LK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | CLAP; mE10; CIPER; IMD37; c-E10; CARMEN; Bcl10 |
Positive Sample: | Mouse ovary |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Membrane raft, perinuclear region. |
Calculated MW: | 26kDa |
Observed MW: | 32kDa |
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 8915 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |