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Bcl-2 Polyclonal Antibody (CAB16776)

SKU:
CAB16776
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IHC
IF
$155 - $431
Frequently bought together:

Description

Bcl-2 Polyclonal Antibody (CAB16776)

The Bcl-2 Polyclonal Antibody (CAB16776) is a valuable tool for researchers studying the Bcl-2 protein, a key regulator of cell survival and apoptosis. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the Bcl-2 protein, this antibody allows for the detection and analysis of Bcl-2 expression in various cell types, making it ideal for studies in cell biology, cancer research, and drug development.Bcl-2 is a crucial protein in the cell's decision to undergo apoptosis, or programmed cell death, and dysregulation of Bcl-2 expression is associated with various diseases, including cancer and autoimmune disorders.

By understanding the role of Bcl-2 in cell survival and apoptosis, researchers can uncover new therapeutic targets and develop novel treatments for these conditions. The Bcl-2 Polyclonal Antibody is a valuable tool for furthering our understanding of Bcl-2 biology and advancing research in these areas.

Product Name:Bcl-2 Polyclonal Antibody
Product Code:CAB16776
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IHC-P, IF/ICC, ELISA
Key Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Recommended Dilution:WB 1:500-1:2000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Positive Samples:293T, HeLa, mouse lung, mouse testis, HCT116
Cellular Location:Endoplasmic reticulum membrane, Mitochondrion outer membrane, Nucleus membrane, Single-pass membrane protein
Customer Validation:IF(Rattus norvegicus)WB(Mus musculus, Homo sapiens, Capra hircus)IHC(Mus musculus)

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Bcl-2 (NP_000624.2).
Sequence:MAHAG RTGYD NREIV MKYIH YKLSQ RGYEW DAGDV GAAPP GAAPA PGIFS SQPGH TPHPA ASRDP VARTS PLQTP AAPGA AAGPA LSPVP PVVHL TLRQA
Synonyms:Bcl-2, PPP1R50
Calculated MW:26kDa
Observed MW:24kDa/26kDa

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