The BCL-2 Polyclonal Antibody (CAB11313) is a valuable tool for research related to B-cell lymphoma 2 (BCL-2), a protein known for its role in regulating cell survival and apoptosis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the BCL-2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in cancer biology and apoptosis research.BCL-2 is a key player in the regulation of apoptosis (programmed cell death) and is frequently dysregulated in cancer, making it a promising target for therapeutic development.
Understanding the function of BCL-2 and its impact on cell survival is critical for advancing our knowledge of cancer biology and identifying potential strategies for targeted treatment. By utilizing the BCL-2 Polyclonal Antibody (CAB11313), researchers can gain insights into the mechanisms underlying cell survival, apoptosis resistance, and cancer progression, ultimately contributing to the development of novel therapeutic approaches.
Product Name:
Bcl-2 Polyclonal Antibody
SKU:
CAB11313
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-239 of human Bcl-2 (NP_000624.2).
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
596
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Bcl-2 Rabbit pAb (CAB11313) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
