The Bcl-2 Polyclonal Antibody (CAB11025) is specifically designed for research involving the Bcl-2 protein, a key regulator of cell apoptosis and survival. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it ideal for use in Western blot applications. By binding to the Bcl-2 protein, this antibody enables researchers to detect and analyze the expression levels of Bcl-2 in various cell types.Bcl-2 is a critical protein involved in the regulation of programmed cell death, making it a significant target for studies in oncology and cell biology. Dysregulation of Bcl-2 expression has been implicated in various diseases, including cancer, making it an important marker for disease prognosis and potential therapeutic strategies.
Understanding the role of Bcl-2 can provide valuable insights into cellular pathways and potential targets for drug development in cancer research. Overall, the Bcl-2 Polyclonal Antibody is a valuable tool for researchers studying the mechanisms of cell survival and apoptosis, particularly in the context of cancer and other diseases where Bcl-2 dysregulation plays a role. Its high reactivity and specificity make it a reliable choice for immunology and oncology research.
Product Name:
Bcl-2 Polyclonal Antibody
SKU:
CAB11025
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-239 of human Bcl-2 (NP_000624.2).
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
596
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse liver, using Bcl-2 Rabbit pAb (CAB11025) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
