The BCL-2 Polyclonal Antibody (CAB0208) is a crucial tool for researchers studying the B-cell lymphoma 2 (BCL-2) protein, a key regulator of apoptosis and cell survival. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the BCL-2 protein, this antibody facilitates the detection and analysis of BCL-2 expression in various cell types, making it an essential component of studies in cancer biology and cell survival mechanisms.BCL-2 is a well-known anti-apoptotic protein that plays a significant role in regulating programmed cell death and maintaining cellular homeostasis. Dysregulation of BCL-2 expression has been implicated in various diseases, including cancer, where increased BCL-2 levels promote cell survival and resistance to chemotherapy.
Research into the function and regulation of BCL-2 is instrumental in developing targeted therapies for cancer and other disorders characterized by disrupted apoptosis pathways.By utilizing the BCL-2 Polyclonal Antibody, researchers can gain valuable insights into the molecular mechanisms governing cell survival and apoptosis, ultimately paving the way for the development of novel therapeutic strategies aimed at manipulating BCL-2 activity for clinical benefit. Whether investigating cancer progression, drug resistance, or cellular stress responses, this antibody serves as a versatile tool for elucidating the intricate role of BCL-2 in health and disease.
Product Name:
Bcl-2 Polyclonal Antibody
SKU:
CAB0208
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Bcl-2 (NP_000624.2).
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
596
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using Bcl-2 Rabbit pAb (CAB0208) at 1:900 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
