The BCCIP Polyclonal Antibody (CAB8586) is a valuable tool for researchers studying the BCCIP protein, which is involved in various cellular processes such as DNA repair and cell cycle regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications.BCCIP, also known as BCC-interacting protein, plays a crucial role in maintaining genomic stability and proper cell division. Dysregulation of BCCIP has been linked to cancer development and progression, making it a promising target for cancer research.
By using the BCCIP Polyclonal Antibody, researchers can detect and analyze BCCIP expression levels in different cell types, providing valuable insights into its function and potential therapeutic implications.Overall, this antibody offers a reliable tool for studying BCCIP and its role in various cellular processes, particularly in the context of cancer biology. Its high reactivity and specificity make it a valuable asset for researchers looking to deepen their understanding of BCCIP and its implications in disease development and treatment.
Product Name:
BCCIP Rabbit Polyclonal Antibody
SKU:
CAB8586
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of human BCCIP (NP_510868.1).
SKOV3,HeLa,Mouse brain,Mouse liver,Mouse small intestine
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
36kDa
Observed MW:
50kDa
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
56647
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using BCCIP Rabbit pAb (CAB8586) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
