BCCIP Rabbit Polyclonal Antibody (CAB8586)
- SKU:
- CAB8586
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | BCCIP Rabbit Polyclonal Antibody |
SKU: | CAB8586 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of human BCCIP (NP_510868.1). |
Sequence: | MASR SKRR AVES GVPQ PPDP PVQR DEEE EKEV ENED EDDD DSDK EKDE EDEV IDEE VNIE FEAY SLSD NDYD GIKK LLQQ LFLK APVN TAEL TDLL IQQN HIGS VIKQ TDVS EDSN DDMD EDEV FGFI SLLN LTER KGTQ CVEQ IQEL VLRF CEKN CEKS MVEQ LDKF LNDT TKPV GLLL SERF INVP PQIA LPMY QQLQ KELA GAHR TNKP CGKC YFYL LISK TFVE AGKN NSKK KPSN KKKA ALMF ANAE EEFF YEKA ILKF NYSV QEES DTCL GGKW SFDD VPMT PLRT VMLI PGDK MNEI MDKL KEYL SV |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:100 - 1:200 |
Synonyms: | TOK1; TOK-1; BCCIP |
Positive Sample: | SKOV3,HeLa,Mouse brain,Mouse liver,Mouse small intestine |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 36kDa |
Observed MW: | 50kDa |
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 56647 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |