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BCAR1 Rabbit Polyclonal Antibody (CAB18270)

SKU:
CAB18270
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

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BCAR1 Rabbit Polyclonal Antibody (CAB18270)

The BCAR1 Polyclonal Antibody (CAB18270) is a valuable tool for research involving BCAR1, a protein involved in cell signaling pathways related to cancer progression and metastasis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the BCAR1 protein, this antibody enables the detection and analysis of BCAR1 expression in various cell types, making it an ideal choice for studies in oncology and cancer research.

BCAR1, also known as breast cancer anti-estrogen resistance 1, plays a crucial role in cell migration, invasion, and resistance to anti-cancer therapies. Its involvement in these processes makes it a promising target for research into cancer development and treatment. Understanding the function of BCAR1 can provide valuable insights into mechanisms of tumor growth and the development of potential therapeutic strategies targeting BCAR1-mediated pathways.

Product Name:BCAR1 Rabbit Polyclonal Antibody
SKU:CAB18270
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 495-612 of human BCAR1 (NP_055382.2).
Sequence:EPQE PLVQ DLQA AVAA VQSA VHEL LEFA RSAV GNAA HTSD RALH AKLS RQLQ KMED VHQT LVAH GQAL DAGR GGSG ATLE DLDR LVAC SRAV PEDA KQLA SFLH GNAS LLFR RTKA TA
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:CAS; CAS1; CASS1; CRKAS; P130Cas; BCAR1
Positive Sample:HeLa,Mouse brain
Cellular Localization:Cell junction, Cytoplasm, focal adhesion.
Calculated MW:93kDa
Observed MW:130kDa

The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer.

Purification Method:Affinity purification
Gene ID:9564
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Mouse brain, using BCAR1 Rabbit pAb (CAB18270) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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