The BCAM Polyclonal Antibody (CAB14747) is a high-quality research tool designed for studying BCAM, also known as Lutheran blood group glycoprotein. This antibody is raised in rabbits and specifically targets the BCAM protein in human samples, making it ideal for use in Western blot applications.BCAM is a cell surface molecule that plays a key role in cell adhesion and is involved in processes such as cell migration, signaling, and development. It is particularly important in the context of blood cell interactions and vascular biology, making it a valuable target for research in areas such as hematology, vascular biology, and cancer research.
By using the BCAM Polyclonal Antibody, researchers can detect and analyze BCAM expression in various cell types, allowing for a better understanding of its functions and potential implications in different diseases. This antibody is a valuable tool for investigators interested in unraveling the role of BCAM in physiological and pathological processes, with the ultimate goal of developing targeted therapies for conditions where BCAM dysregulation plays a role.
Product Name:
CD239/BCAM Rabbit Polyclonal Antibody
SKU:
CAB14747
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 352-547 of human CD239/CD239/BCAM (NP_005572.2).
This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4059
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse lung, using CD239/BCAM Rabbit pAb (CAB14747) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
